PTO

OUR Product

PTO – Phosphothioate Oligonucleotide

Phosphothioate oligonucleotides (PTOs) are modified DNA or RNA molecules in which one sulfur atom replaces an oxygen atom in the internucleotide linkage. This structural modification enhances nuclease resistance and increases stability, making PTOs particularly effective in antisense applications aimed at inhibiting gene expression.

Customizable Options

TAG Copenhagen offers PTO synthesis tailored to meet your specific research needs. Choose from the following configurations:

  • Full PTO: Every internucleotide linkage in the oligonucleotide contains a phosphothioate modification, providing maximum stability.
  • “Thiocap” PTO: Phosphothioate linkages are selectively incorporated at the 3′ or 5′-end for partial protection.
  • Chimera: A hybrid molecule combining stretches of phosphothioate-modified DNA/RNA with unmodified regions.

The level of stability increases with the number of phosphothioate linkages, allowing you to design oligonucleotides that match the demands of your specific applications.

A minimalist top view of transparent medical vials on a light blue surface. Perfect for healthcare content.
Customizable Options

PTO are manufactured to the specifications of our customers

Category

Unmodified PTO
Modified PTO
Plate PTO

Purification method:

Desalted
Reverse Phase Column
RP-HPLC

Scales

40 nmol
200 nmol
1.000 nmol

Delivery Method

Solid
In 200 µL water
Standard Conc. (you add 100 µL water/buffer)
Conc. adjustment (multiple aliquoting and mixing)

Applications of PTO Oligonucleotides

Phosphothioate oligonucleotides are widely used in:

  • Molecular Biology Studies: Used in hybridization and other applications requiring robust, stable oligonucleotides.
  • Antisense Research: Effective for inhibiting gene expression by targeting complementary RNA sequences.
  • Therapeutic Development: Ideal for creating stable nucleic acid-based therapies due to their resistance to enzymatic degradation.

Manufactured to Your Specifications

All PTO oligonucleotides are custom-made according to your precise requirements. Whether you need full PTO coverage, selective modifications, or complex chimera designs, TAG Copenhagen ensures high-quality synthesis tailored to your project.

Let TAG Copenhagen help you harness the stability and versatility of phosphothioate oligonucleotides for your next research breakthrough.

Order information

How to Order

Please contact our customer service for a quotation and when ordering Phosphothioate oligonucleotide (PTO).

  • Visit our How to Order page to learn how to become a customer and place your first order.
  • Check out our FAQ page for information on payment, order status, and more.

You can also contact us directly via email or phone for personalized support.

Order by E-mail

Please contact our customer service for a quotation and when ordering Phosphothioate oligonucleotide.

NEED A PTO

Contact us Today